RecruitingEarly Phase 1NCT07053293

SGLT2i, Hepatic Glucose Production, and SNS

Protocol II: SGLT2i, Hepatic Glucose Production, and Sympathetic Nervous System (SNS)


Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

22 participants

Start Date

Jan 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

In this study, PI will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) that the increases in ketone production and lipolysis can be prevented by concomitant administration of the thiazolidinedione pioglitazone. Principal Investigator (PI) will conduct five distinct experiments to test this hypothesis in patients with T2D. To examine the role of the SNS on the empagliflozin-induced stimulation of EGP, lipolysis, and ketone production in T2D by comparing the effect of empagliflozin versus empagliflozin plus propranolol.


Eligibility

Min Age: 30 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study investigates how a class of diabetes medications called SGLT2 inhibitors (such as empagliflozin or dapagliflozin) affect how the liver produces glucose and how the nervous system regulates blood sugar. Understanding these effects could improve how we use these medications to treat type 2 diabetes and heart failure. **You may be eligible if...** - You have type 2 diabetes or heart failure being treated with an SGLT2 inhibitor - You are in otherwise stable health - You meet the specific age and health criteria set by the study **You may NOT be eligible if...** - You have type 1 diabetes - You have significant kidney impairment - You have conditions that would make study procedures unsafe - You are unable to attend study visits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEmpagliflozin 25 MG

A medication used in the management and treatment of type 2 diabetes mellitus. It is in the sodium-glucose co-transporter (SGLT-2) class of medications.


Locations(1)

Texas Diabetes Institute/UH

San Antonio, Texas, United States

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NCT07053293


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