SGLT2i, Pioglitazone, and Ketone Production in T2D

This study examines how combining SGLT2 inhibitors (a class of diabetes medications) with pioglitazone (another diabetes drug) affects the body's production of ketones — natural energy molecules. Researchers want to understand whether this combination is safe and how it influences energy metabolism in people with type 2 diabetes. **You may be eligible if...** - You have type 2 diabetes - You are currently taking an SGLT2 inhibitor - You are not using insulin - Your blood sugar is reasonably controlled - You meet the overall health requirements **You may NOT be eligible if...** - You have type 1 diabetes - You have significant heart failure, liver disease, or kidney impairment - You are currently taking pioglitazone - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.