RecruitingNot ApplicableNCT07056361

Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control

VOP/VIM Direct Electrical Stimulation Increases Motor Cortex Excitability and Motor Output


Sponsor

Jorge Gonzalez-Martinez

Enrollment

60 participants

Start Date

Dec 16, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

In this study the investigators aim to enroll patients scheduled to undergo deep brain stimulation (DBS) implantation for movement disorders for intra-operative testing. In addition to standard-of-care surgical procedure to implant deep brain stimulation electrode leads, participants will also be stimulated and recorded from cortical areas by a temporary strip electrode (1X6) in the subdural space. The electrodes will be connected to external stimulators and a series of experiments will be performed to assess effects of the DBS on movement quality and electrophysiology measures. Results of this study will elucidate the biological mechanisms related to deep brain stimulation in modulating motor and speech function in patients with abnormal movement disorders.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether stimulating specific areas of the brain (called VOP/VIM) with small electrical impulses during deep brain stimulation (DBS) surgery can improve movement and muscle control in patients with essential tremor or Parkinson's disease. The stimulation occurs while the patient is already having their planned DBS surgery, so no extra procedure is needed. **You may be eligible if...** - You have essential tremor or Parkinson's disease - You are already scheduled for deep brain stimulation (DBS) surgery at UPMC Presbyterian Hospital - Your insurance coverage for the standard surgery will not be affected by study participation **You may NOT be eligible if...** - You have a history of seizures - You have severe tremor in both arms that prevents you from completing simple movement tasks Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DEVICEDirect cortical stimulation and deep brain stimulation of motor thalamus

All participants enrolled will undergo implantation of deep brain stimulation electrode leads for treatment of movement disorders. In addition to standard-of-care subcortical mapping using micro-electrode recording (MER) and macrostimulation mapping during DBS placement, cortical local field potentials (LFPs) will be simultaneously recorded from primary motor (M1) and somatosensory (S1) cortical areas by placement of a temporary strip electrode (1X6) in the subdural space. The strip electrode over M1 will be used to produce motor evoked potentials to contralateral hand muscles from direct cortical stimulation (DCMEPs). Cortical and subcortical LFPs will be obtained alongside electromyographic (EMG) data while the patient performs contralateral upper extremity movement tasks and a variety of articulation exercises.


Locations(1)

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07056361


Related Trials