The Motor Activity - Subjective Energy (MASE) Project
The Motor Activity - Subjective Energy (MASE) Project: Neurobiological and Digital Phenotyping Towards Digital Mental Health Interventions in Depression
University of Bern
180 participants
Sep 2, 2025
INTERVENTIONAL
Conditions
Summary
This approach utilizes accelerometry to measure NEA and electronic diaries for real-time psychological assessments, overcoming limitations of traditional methods such as retrospective bias and low ecological validity. Brief episodes of physical activity in daily life, which are distinctly different from structured exercise sessions, are generally linked to improved affective well-being. Notably, feelings of energy are particularly associated with incidental, unstructured, and non-exercise activities. Clinically, psychomotor retardation and diminished mood are key diagnostic features of MDD, with evidence suggesting that lower motor activity differentiates MDD patients from controls and that increased activity correlates with treatment response. In this context, the MASE project aims to design personalized BA interventions that focus on increasing NEA and, in turn, enhancing subjective energy levels to reduce depressive symptoms and prevent relapse.
Eligibility
Inclusion Criteria4
- Sufficient knowledge of the German language
- Written informed consent.
- Score \> 15 on the Montgomery Asberg Depression rating scale (MADRS) for MDD group.
- Remission within the past year and exhibit a MADRS score \< 10 for at least one month for rMDD group
Exclusion Criteria8
- Pregnancy at baseline
- Claustrophobia
- Pacemaker
- Artificial heart valves
- Active implants
- Other psychiatric disorders
- Acute suicidality, change of medication / psychotherapy during the intervention (not dosage but substance).
- For healthy participants: history of any mental health condition or first-degree relative with affective / psychotic disorder
Interventions
The 5-week intervention to assess the effects of non-exercise activity on the activity-subjective energy association incorporates two high-intensity Ambulatory Assessment (AA) weeks at the beginning and end, with a tapered 3-week Ecological Momentary Intervention (EMI) phase in between. Momentary targeted micro interventions (JITAIs) with a Within-Person-Encouragement Design (WPED) are used to tailor the activity to the individual situation and phenotype of each participant.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07059234