RecruitingNot ApplicableNCT07059234

The Motor Activity - Subjective Energy (MASE) Project

The Motor Activity - Subjective Energy (MASE) Project: Neurobiological and Digital Phenotyping Towards Digital Mental Health Interventions in Depression


Sponsor

University of Bern

Enrollment

180 participants

Start Date

Sep 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This approach utilizes accelerometry to measure NEA and electronic diaries for real-time psychological assessments, overcoming limitations of traditional methods such as retrospective bias and low ecological validity. Brief episodes of physical activity in daily life, which are distinctly different from structured exercise sessions, are generally linked to improved affective well-being. Notably, feelings of energy are particularly associated with incidental, unstructured, and non-exercise activities. Clinically, psychomotor retardation and diminished mood are key diagnostic features of MDD, with evidence suggesting that lower motor activity differentiates MDD patients from controls and that increased activity correlates with treatment response. In this context, the MASE project aims to design personalized BA interventions that focus on increasing NEA and, in turn, enhancing subjective energy levels to reduce depressive symptoms and prevent relapse.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria4

  • Sufficient knowledge of the German language
  • Written informed consent.
  • Score \> 15 on the Montgomery Asberg Depression rating scale (MADRS) for MDD group.
  • Remission within the past year and exhibit a MADRS score \< 10 for at least one month for rMDD group

Exclusion Criteria8

  • Pregnancy at baseline
  • Claustrophobia
  • Pacemaker
  • Artificial heart valves
  • Active implants
  • Other psychiatric disorders
  • Acute suicidality, change of medication / psychotherapy during the intervention (not dosage but substance).
  • For healthy participants: history of any mental health condition or first-degree relative with affective / psychotic disorder

Interventions

BEHAVIORALNon-exercise activity

The 5-week intervention to assess the effects of non-exercise activity on the activity-subjective energy association incorporates two high-intensity Ambulatory Assessment (AA) weeks at the beginning and end, with a tapered 3-week Ecological Momentary Intervention (EMI) phase in between. Momentary targeted micro interventions (JITAIs) with a Within-Person-Encouragement Design (WPED) are used to tailor the activity to the individual situation and phenotype of each participant.


Locations(1)

University of Bern

Bern, Switzerland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07059234


Related Trials