Molecular and ctDNA Characterization of High-Risk Endometrial Cancer

This study collects tumor samples and blood (including circulating tumor DNA) from people with high-risk endometrial (uterine) cancer to better understand what drives aggressive disease and help develop more targeted future treatments. **You may be eligible if...** - You are 18 years or older - You are scheduled for complete surgical staging for endometrial cancer at Mayo Clinic (including removal of the uterus and ovaries, and lymph node evaluation) - Your cancer has features suggesting it is high-risk — such as high-grade tissue on biopsy, deep tumor invasion into the uterine wall, large tumor size, or certain aggressive cancer subtypes **You may NOT be eligible if...** - You are not having surgery at Mayo Clinic - Your cancer does not have high-risk features - You are unable to consent to the research procedures Talk to your doctor to see if this trial is right for you.