RecruitingNot ApplicableNCT07062172

Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

Sponsor

University of California, Irvine

Enrollment

1,753 participants

Start Date

May 8, 2025

Study Type

INTERVENTIONAL

Conditions

Lung Cancer Driver Mutation

Summary

This is a single-armed screening research study which screens immediate family member of lung cancer patients with a driver mutation to see if lung cancer can be inherited and whether researchers can find lung cancer early. Immediate family members of lung cancer patients will be 40-80 years old and screened using a low dose CT scan.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This trial screens family members of lung cancer patients who have a specific gene mutation to find early-stage lung cancer before symptoms appear. **You may be eligible if...** - You have a current lung cancer diagnosis with a known driver mutation (Cohort A), OR - You are a first-degree relative (parent, sibling, or child) of a Cohort A patient, aged 40–80, with fewer than 20 pack-years of smoking history (Cohort B) - You are able to undergo a low-dose chest CT scan (Cohort B) **You may NOT be eligible if...** - You have a prior history of lung cancer (Cohort B) - You have unexplained significant weight loss or coughing up blood (Cohort B) - You are pregnant (Cohort B) - You have had another cancer in the past 5 years (some exceptions apply) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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