RecruitingNot ApplicableNCT07062770
Assessment of Circuit Rebreathing During CPAP Therapy
Assessment of Circuit Rebreathing During Continuous Positive Airway Pressure (CPAP) Therapy
Sponsor
Brigham and Women's Hospital
Enrollment
13 participants
Start Date
May 27, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).
Eligibility
Min Age: 21 YearsMax Age: 70 Years
Inclusion Criteria5
- Moderate to severe OSA (AHI>20)
- Self-reported CPAP users or have previously used CPAP
- Self-reported holding pressure of maximum 13 cmH2O (if known)
- Age: 21-70
- BMI: 18-40 kg/m2
Exclusion Criteria5
- Self-reported severe mouth-breathing
- Requirement for nocturnal supplemental oxygen or other ventilatory support
- Severe cardiovascular or pulmonary disease
- Any unstable or acute medical condition
- Any additional sleep disorder, including insomnia, except for OSA.
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Interventions
DEVICEContinuous positive airway pressure (CPAP)
Subjects will be administered either 0, 5 or 10 cmH2O
OTHERMask exhaust port flow
Subjects will be administered varying levels of exhaust flow: 35, 23, 18, 13 and 8 L/s
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07062770
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