RecruitingNot ApplicableNCT07062783

Effect of Aerobic Exercise on Biomarkers in Depression

The Effect of Respiratory and Aerobic Exercises on Neuroprotective and Inflammation Biomarkers in Patients Diagnosed With Major Depression


Sponsor

Kutahya Health Sciences University

Enrollment

40 participants

Start Date

Aug 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to investigate changes in the levels of biomarkers (IGF-1, FGF2, and EGF) involved in neuron development in patients diagnosed with major depression through the effects of breathing exercises and aerobic exercise, as well as to examine the levels of biomarkers (TNF-α, IL-6, and IL-1) and oxidative stress (TAS, TOS, MDA, and F2-isoprostane) that are thought to play a role in the pathophysiology of depression.


Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria3

  • Individuals who volunteer to participate in the study,
  • Between the ages of 18 and 40,
  • Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria

Exclusion Criteria3

  • Individuals with chronic conditions accompanying depression,
  • Those with walking difficulties
  • Those with respiratory system disorders

Interventions

OTHERBreathing exercise

Volunteers participating in the study who were included in the experimental group performed breathing exercises every day for three weeks. They were taught to focus their attention on the hand on their abdominal area while breathing slowly through their nose and to increase abdominal movement while reducing chest movement. They were warned that during inspiration, as air filled their lungs, the hand on their abdomen should rise upward and the hand on their chest should not move excessively. Participants continued the training until they performed the exercise correctly. The diaphragmatic breathing exercise was performed for 10 minutes in the supine position during the first week, in the semi-sitting and/or sitting position during the second week, and in the standing position during the final week.

OTHERAerobic Exercise

The ratios determined as reference values for walking training in healthy adults (reference value for women = (2.11\*height) - (2.29\*body weight) - (5.78\*age) + 667 meters - reference value for men = (7.57\*height) - (1.76\*body weight) - (5.0 2\*age) - 309 meters) was performed at 80% intensity for at least 30 minutes on at least 3 days a week for 3 weeks. Aerobic exercise was considered for 3 weeks to facilitate adaptation to exercise and sustainability.


Locations(1)

Kutahya Health Sciences University

Kütahya, Merkez, Turkey (Türkiye)

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NCT07062783


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