Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients
Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in Patients With COPD
Eastern Switzerland University of Applied Sciences
52 participants
Jul 23, 2025
INTERVENTIONAL
Conditions
Summary
Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.
Eligibility
Inclusion Criteria4
- Aged ≥18 years
- Stable clinical condition for \>3 weeks (e.g., no exacerbations)
- Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
- Informed consent documented by signature
Exclusion Criteria6
- Severe daytime resting hypoxemia (SpO₂ \<88%)
- Long-term oxygen therapy
- Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
- Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
- Women who are pregnant or breastfeeding
- Enrolment in another clinical trial involving active treatment
Interventions
Standard ambiant air will be breathed during endurance training. ambiant air
SSOT and sham air (5l/min) will be applied with the oxygen concentrator EverFloTM via nasal cannula during training
Standard ambiant air will be breathed during endurance training. ambiant air
Locations(2)
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NCT07063563