RecruitingNCT07067632

To Study the Mortality Outcome of Controlled Blood Pressure Participants

Mortality Outcome of Controlled Hypertension in Randomized Controlled or Open-label Study Intentionally Directed Intervention Effect Blood Pressure: A Systematic Review and Meta-Analysis

Sponsor

DejthidaNathaphong

Enrollment

100 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Hypertension (HTN)Valid MeSH Conditions

Summary

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials. To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Adults ≥18 years with diagnosed hypertension
Blood pressure controlled at target values defined by the study (e.g., \<140/90 mmHg or \<130/80 mmHg)
Any comorbidity allowed unless the study focuses on pregnancy or pediatric population

Exclusion Criteria4

Observational or retrospective studies
Pediatric or pregnant participants
Case reports, editorials, or conference abstracts without full data
Studies not reporting mortality outcomes separately for controlled BP

Interventions

DRUGAntihypertensive treatment

Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP Control groups receiving placebo, standard of care, or no intervention