RecruitingNCT07067632

To Study the Mortality Outcome of Controlled Blood Pressure Participants

Mortality Outcome of Controlled Hypertension in Randomized Controlled or Open-label Study Intentionally Directed Intervention Effect Blood Pressure: A Systematic Review and Meta-Analysis

Sponsor

DejthidaNathaphong

Enrollment

100 participants

Start Date

Jul 1, 2025

Study Type

OBSERVATIONAL

Conditions

Hypertension (HTN)Valid MeSH Conditions

Summary

Despite advances in antihypertensive therapy, some patients with well-controlled blood pressure still experience fatal outcomes. This paradox raises critical questions about the efficacy of blood pressure-targeted interventions and whether BP control alone ensures survival. This systematic review and meta-analysis aims to evaluate all-cause mortality and cardiovascular death among hypertensive patients who achieved BP targets in RCTs or open-label trials. To determine whether achieving controlled blood pressure through intentional intervention (pharmacological or procedural) in RCTs or open-label studies reduces mortality (all-cause and cardiovascular) in hypertensive patients.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is an observational study (no experimental treatment involved) that examines what happens to adults who have well-controlled high blood pressure over time — specifically, how blood pressure control relates to long-term survival and death rates. Researchers want to understand whether keeping blood pressure within target ranges truly reduces mortality risk across a wide range of patients. **You may be eligible if...** - You are 18 or older - You have been diagnosed with high blood pressure (hypertension) - Your blood pressure is currently controlled at or below target values (such as below 140/90 or 130/80 mmHg) - You have any other medical conditions (aside from pregnancy or being a child) **You may NOT be eligible if...** - You are under 18 or currently pregnant - Your case is being submitted as a conference abstract, editorial, or case report without full data - Mortality outcome data is not separately reported for controlled blood pressure participants in your records Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAntihypertensive treatment

Any intervention (pharmacological, device-based, lifestyle) intentionally directed at lowering BP Control groups receiving placebo, standard of care, or no intervention