RecruitingNCT07480265

Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension

Relationship Between Elevated Homocysteine Levels and Early Diastolic Dysfunction in Newly Diagnosed Hypertensive Patients

Sponsor

Necmettin Erbakan University

Enrollment

500 participants

Start Date

Jun 2, 2025

Study Type

OBSERVATIONAL

Conditions

Hypertension (HTN)Diastolic Dysfunction Hyperhomocysteinemia

Summary

This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension. Adult patients diagnosed with essential hypertension within the previous 6 months will undergo clinical assessment, ambulatory blood pressure monitoring, electrocardiography, laboratory testing, and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis when image quality is adequate. Participants will be classified according to plasma homocysteine level using, and patients with elevated and normal homocysteine levels will be compared with respect to diastolic dysfunction and left ventricular and left atrial global longitudinal strain parameters. Clinical, laboratory, and echocardiographic data will also be used to develop a machine-learning based model for prediction of H-type hypertension.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether elevated levels of homocysteine — an amino acid in the blood — are linked to early signs of heart stiffness (called diastolic dysfunction) in people who have just been diagnosed with high blood pressure. Catching heart changes early may help prevent more serious heart disease. **You may be eligible if...** - You are 18 or older - You have been newly diagnosed with high blood pressure (hypertension) within the past 6 months - You are willing and available for blood tests, heart monitoring, and an echocardiogram (heart ultrasound) **You may NOT be eligible if...** - Your blood pressure is very hard to control (resistant hypertension) or has a known secondary cause - You had a heart attack or major surgery in the past 6 months - You have known heart failure, irregular heart rhythm (atrial fibrillation), severe valve disease, or congenital heart disease - You have chronic kidney disease or anemia - You currently take folate, vitamin B12, or vitamin B6 supplements - Your heart ultrasound images are not clear enough for analysis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTHomocysteine Measurement and Echocardiography

Peripheral venous blood sampling for plasma homocysteine measurement and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis.