Weaning Approaches for Vasopressin in Sepsis
Weaning Approaches for Vasopressin in Sepsis - a Randomized Controlled Trial of Titrated Versus Abrupt Discontinuation During Stabilization of Septic Shock - WAVES Trial
Hospital Nossa Senhora da Conceicao
82 participants
Oct 1, 2025
INTERVENTIONAL
Conditions
Summary
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
Eligibility
Inclusion Criteria4
- Age over 18 years
- Admitted to the Intensive Care Unit
- Patients with vasopressor dependent sepsis
- Receiving combined norepinephrine and vasopressin therapy
Exclusion Criteria2
- Withdrawal/reduction of vasopressin related to a plan of treatment limitation or palliative care
- Withdrawal/reduction of vasopressin associated with the initiation of adrenaline or any other vasopressor
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Interventions
The titrated group will follow the vasopressin weaning protocol used in the DOVSS study (reduction of 0.01 U/min per hour).
The abrupt group will discontinue the vasopressin infusion at the time of randomization, without dose titration.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07067866