Clinical Study of the Pulsed Electric Field Ablation System in Chronic Obstructive Pulmonary Disease

This study is testing a new procedure called pulsed electric field (PEF) ablation — which uses targeted electrical pulses delivered through a bronchoscope (a thin tube passed into the airways) to destroy mucus-producing glands — to reduce chronic cough and phlegm in people with COPD. **You may be eligible if...** - You are 35 to 80 years old and have COPD with chronic bronchitis (cough and phlegm for at least 3 months per year, 2 years in a row) - Your symptoms score high on standard COPD questionnaires (CAT and SGRQ) - You are already on standard COPD medications including a long-acting bronchodilator - You are able to have two bronchoscopies under general anesthesia - You have not smoked in the past 2 months **You may NOT be eligible if...** - You have an active lung infection or lung cancer - You have a pacemaker or implanted electronic heart device - You have had prior lung surgery, lung valve placement, or significant emphysema - You have uncontrolled heart disease, GERD, or severe pulmonary hypertension - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.