Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms
University of Minnesota
125 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.
Eligibility
Inclusion Criteria3
- Adults who are relatively healthy and aged 21-70 years.
- Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
- Must either (1) use CBD daily/regularly or (2) not use CBD regularly.
Exclusion Criteria6
- Participated in previous acute stress studies that included a similar stress induction.
- Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
- Self-reported current pregnancy.
- Self-reported current use of illicit substances (other than cannabis).
- Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
- Students of the principal researcher
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Interventions
Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07069478