Stress Clinical Trials

1,175 recruitingLast updated: June 17, 2026

There are 1,175 actively recruiting stress clinical trials across 76 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Boston, Massachusetts, United States, New York, New York, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Stress Trials at a Glance

1,175 actively recruiting trials for stress are listed on ClinicalTrialsFinder across 6 cities in 76 countries. The largest study group is Not Applicable with 720 trials, with the heaviest enrollment activity in Boston, New York, and Houston. Lead sponsors running stress studies include VA Office of Research and Development, Massachusetts General Hospital, and Karolinska Institutet.

Treatments under study

About Stress Clinical Trials

Looking for clinical trials for Stress? There are currently 323 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Stress trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Stress clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 1,175 trials

Recruiting
Not Applicable

Cognitive Processing Therapy (CPT) for Perinatal Posttraumatic Stress Disorder (PTSD)

PregnancyPosttraumatic Stress Disorder (PTSD)
University of Texas at Austin60 enrolled1 locationNCT07060144
Recruiting
Not Applicable

Utility of a Mobile Application for Young Women With Breast Cancer

Breast CancerCancer Distress
Wake Forest University Health Sciences120 enrolled1 locationNCT07009093
Recruiting
Not Applicable

Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa

DepressionPregnancy RelatedMedication Adherence+1 more
Boston University Charles River Campus118 enrolled2 locationsNCT05624931
Recruiting
Not Applicable

Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study

Depressive DisorderPercutaneous Coronary Intervention (PCI)Acute Coronary Syndrome (ACS)+5 more
Jing Han120 enrolled1 locationNCT07454070
Recruiting
Phase 4

The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response

surgical stress responseThyroid CancerThyroid and Parathyroid Surgery+1 more
University Hospital Dubrava48 enrolled1 locationNCT07600580
Recruiting
Phase 4

Computational Assessment of GABA Receptor Modulation in PTSD

Stress Disorders, Post-Traumatic
VA Office of Research and Development150 enrolled1 locationNCT06852469
Recruiting
Phase 2

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

InfectionsAcute Respiratory Distress Syndrome
BioAegis Therapeutics Inc.600 enrolled70 locationsNCT05947955
Recruiting
Not Applicable

Transcranial Magnetic Stimulation in Veterans With PTSD

PTSD - Post Traumatic Stress Disorder
White River Junction Veterans Affairs Medical Center20 enrolled1 locationNCT07336251
Recruiting
Not Applicable

Training in Evidence-based Treatments in Psycho-Oncology

PainDepression, AnxietyDistress, Emotional+2 more
Massachusetts General Hospital115 enrolled1 locationNCT05674357
Recruiting
Not Applicable

Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

Post Traumatic Stress Disorder (PTSD)HIV
Montefiore Medical Center20 enrolled1 locationNCT05929911
Recruiting
Not Applicable

Minority Stress Counseling for LGBTQ+ Individuals

Minority Stress
University of Alabama at Birmingham80 enrolled1 locationNCT06614868
Recruiting
Phase 3

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

Post Traumatic Stress Disorder
Transcend Therapeutics300 enrolled32 locationsNCT07456696
Recruiting
Not Applicable

A Randomized Controlled Trial to Assess the Impact of Live and Recorded Music-Based Interventions on Pre-operative Stress, Mood, Pain and Biomarkers, in Neurosurgical Patients (Music-STAR Trial)

PainStress
M.D. Anderson Cancer Center132 enrolled1 locationNCT06536504
Recruiting
Not Applicable

Integrated Health Care for PTSD

Posttraumatic Stress Disorder (PTSD)
Veterans Medical Research Foundation300 enrolled5 locationsNCT07220681
Recruiting

Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974

Post Traumatic Stress Disorder (PTSD)Alcohol Use Disorder (AUD)
Yale University160 enrolled1 locationNCT07488819
Recruiting
Not Applicable

People Bereaved by Violent Death : Negative Event Biases and Temporal Perception

Post Traumatic Stress Disorder
Hôpital le Vinatier61 enrolled1 locationNCT05874362
Recruiting
Not Applicable

The Effect of Virtual Reality-Based Intervention on Anxiety, Stress, and Pain in Women Undergoing Colposcopy: A Randomized Controlled Trial

colposcopyStressAnxiety+2 more
Osmaniye Korkut Ata University60 enrolled1 locationNCT07650422
Recruiting
Early Phase 1

A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome

ARDS (Moderate or Severe)ARDS (Acute Respiratory Distress Syndrome)
Shanghai Zhongshan Hospital24 enrolled1 locationNCT07558538
Recruiting
Not Applicable

Assessing MB-Spirit for Psychological Well-being

Stress
Sara W Lazar44 enrolled2 locationsNCT07325448
Recruiting

Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.

ARDS (Acute Respiratory Distress Syndrome)
University of Pennsylvania36 enrolled1 locationNCT07125079