Effects of Intermitted Theta Burst Stimulation (iTBS) on Motor Recovery of Upper Extremity in Chronic Stroke Patients
Neuroplastic Changes and Effects of Intermittent Theta Burst Stimulation (iTBS) on Motor Recovery of Upper and Lower Extremity in Chronic Stroke Patients
Danderyd Hospital
48 participants
Nov 1, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of upper extremity in the chronic phase after stroke. It also seeks to explore the underlying mechanisms by investigating changes of functional and structural brain networks.
Eligibility
Inclusion Criteria3
- Age over 18
- Chronic stroke (\>6 months)
- Residual hemiparesis FM-UE\>17
Exclusion Criteria7
- Metal implants
- Epilepsy/seizures
- Pregnancy
- Claustrophobia (related to MRIs exams)
- Severe cognitive impairment
- Untreated or unstable depression/anxiety
- Other disabilities prohibiting intensive physical training
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Interventions
iTBS protocol: 600 pulses at 80% of AMT for 190 sec on the ipsilesional motor cortex, targeted with the support of a neuronavigational system, 15 sessions over a period of 5 weeks
It is identical to its active version, replicates operational sounds, and delivers a very shallow magnetic field to mimic the sensation of magnetic stimulation
Locations(1)
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NCT07073248