RecruitingNCT07076147

Breast Cancer Screening Adherence for Women at Moderate Risk for Breast Cancer

Sponsor

University of Southern California

Enrollment

150 participants

Start Date

Jun 2, 2025

Study Type

OBSERVATIONAL

Conditions

Breast Carcinoma

Summary

This study assesses breast cancer screening adherence for women at moderately increased risk for developing breast cancer based on gene mutation status or empiric risk model estimates. It also seeks to determine facilitators and barriers to screening.

Eligibility

Sex: FEMALEMin Age: 30 YearsMax Age: 75 Years

Inclusion Criteria8

\* \>= 30 years
=\< 75 years
Women with either:
Genetic test results showing moderately increased breast cancer risk due to a pathogenic/likely pathogenic variant in ATM, CHEK2, BARD1, RAD51C, or RAD51D (Mutation carrier group) OR
Calculated lifetime breast cancer risk estimates between 20% and 40% according to the Tyrer-Cuzick V8.0B empiric risk model (Empiric risk group)
Patients provided breast cancer risk assessments by genetic counselors at USC Norris or LA General Hospital beginning in 2021 and at least 12 months ago
Women recommended to undergo annual breast MRI and/or annual mammogram beginning at the time of their genetic counseling risk assessment
English or Spanish speaking patients

Exclusion Criteria4

\* History of breast cancer before genetic counseling at University of Southern California (USC)
Any metastatic cancer diagnosis at time of genetic counseling risk assessment
Deceased
Patient underwent a risk reducing mastectomy before their genetic counseling risk assessment