RecruitingNot ApplicableNCT07076888

Aerobic Exercises and Hemodialysis Patients

Impact of Aerobic Exercises on Serum Uric Acid Levels in Hemodialysis Patients

Sponsor

Cairo University

Enrollment

32 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Hemodialysis

Summary

Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Aerobic exercise has been shown to improve cardiovascular health and reduce SUA levels in various populations, suggesting potential benefits for HD patients. Objective: This study aimed to investigate the impact of aerobic exercise on serum uric acid (SUA) levels, functional capacity, and quality of life (QoL) in patients undergoing hemodialysis (HD). Methods: This randomized controlled trial will recruit 32 participants, aged 40-60, undergoing HD. The intervention group (Group A) will participate in a structured 6-week aerobic exercise program, while the control group (Group B) will receive only conventional physical therapy. Pre- and post-intervention assessments included SUA levels, the Six-Minute Walk Test (6MWT), and the Kidney Disease Quality of Life Short Form (KDQOL-SF™)

Eligibility

Min Age: 40 YearsMax Age: 60 Years

Inclusion Criteria4

Hemodialysis patients aged 40-60years
Patients are medically stable and able to participate in physical activity.
Participants are able to understand the commands.
Participants must be stable on hemodialysis for at least 3 months.

Exclusion Criteria3

Patients with significant cardiovascular or respiratory diseases, or other conditions that could impair their ability to exercise.
Severe cognitive impairment or psychiatric conditions that could interfere with study participation.
patients with acute medical conditions.

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Interventions

OTHERAerobic Exercises

1. Timing of Exercise: Aerobic exercises were performed on non-dialysis days. This scheduling avoids post-dialysis fatigue and hypotensive effects, optimizing patient safety and performance. 2. Frequency: Patients was engaged in aerobic exercise 3 times per week on non-consecutive days, to allow sufficient recovery time between sessions. 3. Duration of Each Session: * Total Duration: Each exercise session was last between 20 to 45 minutes. * Warm-Up: 5-10 minutes of low-intensity activity (e.g., slow walking). * Main Exercise: 15-30 minutes of moderate-intensity aerobic exercise. * Cool-Down:\*5-10 minutes of gradual reduction in intensity. 4. Exercise Modality: * Options: Patients may choose between treadmill walking or using a stationary bike, depending on their preference, physical condition. * Variety: To maintain engagement and reduce monotony, patients can alternate between treadmill and bike exercises. 5. Intensity: Use moderate-intensity exercise, aiming for 60-70% of the p

OTHERConventional Program

1\. Breathing Exercises \- Diaphragmatic Breathing: Instruct patients to place one hand on their chest and the other on their abdomen. They should inhale deeply through their nose, allowing the abdomen to rise, and then exhale slowly through their mouth. This breathing technique has been shown to reduce stress, improve respiratory efficiency, and enhance relaxation . For optimal benefits, patients should practice this for 5-10 minutes, 2-3 times a day. Stretching Exercises Hamstring Stretch: Instruct patients to sit with one leg extended straight out in front of them and the other leg bent. They should reach towards the toes of the extended leg while keeping their back straight. Hold the stretch for 20-30 seconds and repeat the stretch 2-3 times per leg. Lower Limb Circulatory Exercises Ankle Pumps: While lying down or seated, instruct patients to alternately point and flex their feet to stimulate circulation and improve lower leg mobility. Perform 20-30 pumps per foot, 2-3 times a day