RecruitingPhase 1NCT07082803

TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

An Open-Label, Multicenter, Phase 1 Trial to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of TLN-121 as a Single Agent and in Combination With Other Anti-Lymphoma Agents, in Patients With Relapsed or Refractory Non-Hodgkin Lymphomas


Sponsor

Treeline Biosciences, Inc.

Enrollment

180 participants

Start Date

Jun 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The primary purpose of this study is to evaluate the safety, pharmacokinetics,, and preliminary anti-tumor activity of TLN-121 as a single agent and in combination with other anti-lymphoma therapies in patients with relapsed or refractory Non-Hodgkin Lymphomas


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new oral drug called TLN-121 in people with several types of non-Hodgkin lymphoma (a blood cancer) that have come back or stopped responding to prior treatment. The study includes people with certain types of B-cell lymphoma (such as large B-cell lymphoma and follicular lymphoma) and T-cell lymphoma. **You may be eligible if...** - You have confirmed relapsed or refractory non-Hodgkin lymphoma (specific eligible subtypes are listed in the study) - You have received at least 1–2 prior treatments depending on your lymphoma type - You have measurable cancer on imaging and are in good general health (ECOG 0–1) **You may NOT be eligible if...** - Your lymphoma has spread to the brain or spinal cord (CNS involvement) - You have had a stem cell transplant within the past 60–90 days or CAR T-cell therapy within the past 4 weeks - You have a serious medical illness or active uncontrolled infection - You are pregnant or breastfeeding - You have conditions that would prevent you from absorbing the oral medication Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTLN-121

Specified dose on specified days.

DRUGTLN-254

Specified dose on specified days.

DRUGTLN-121

Specified dose on specified days.


Locations(12)

Stanford Medicine Cancer Center

Palo Alto, California, United States

The START Center for Cancer Care - Midwest

Grand Rapids, Michigan, United States

Washington University School of Medicine

St Louis, Missouri, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

SCRI Oncology Partners

Nashville, Tennessee, United States

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Macquarie University Hospital

Macquarie Park, New South Wales, Australia

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Cabrini Health

Malvern, Victoria, Australia

Peter MacCallum Cancer Centre

Melbourne, Victoria, Australia

Linear Clinical Research

Perth, Western Australia, Australia

BC Cancer - Vancouver

Vancouver, British Columbia, Canada

View Full Details on ClinicalTrials.gov

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NCT07082803


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