RecruitingNot ApplicableNCT07083089

Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)

Phenotyping of Audition in Patients With Early Stage of Neurodegenerative Disorders (Alzheimer and Parkinson' Diseases)

Sponsor

Cilcare SAS

Enrollment

309 participants

Start Date

Mar 24, 2025

Study Type

INTERVENTIONAL

Conditions

Healthy Participants Mild Cognitive Impairment (MCI) Amnestic Parkinson Disease (PD)

Summary

The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population. Specific focus is made on patients with speech-in-noise intelligibiltiy deficit despite normal tonal audiograms referred to as hidden hearing loss, with potential identification of associated biomarkers.

Eligibility

Min Age: 50 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether hearing problems are connected to the early stages of Alzheimer's and Parkinson's diseases. Researchers want to understand if hearing loss could be an early warning sign of these brain conditions. **You may be eligible if...** - You are between 50 and 85 years old - You speak French as your native language - You have been diagnosed with mild memory problems (mild cognitive impairment), early Parkinson's disease, or are a healthy volunteer with no memory problems - You are in generally good health and able to attend study visits - You are enrolled in French public health insurance **You may NOT be eligible if...** - You have severe hearing loss that cannot be corrected with hearing aids - You have a history of certain brain or nerve conditions unrelated to the study - You are currently taking certain medications that affect brain function - You are unable to follow study procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERThorough Hearing assessment

Otoscopy Tympanometry Tonal audiometry (air and bone conduction) Vocal audiometry (in silence and in noise) Distorsion Products of OtoAcoustic Emissions (DPOAE) Middle Ear Muscle Reflex (MEMR) Auditory Brainstem Response (ABR) Electrocochleography (EcochG)