Efficacy of LcS-Fermented Milk on Constipation-Related Symptoms in Filipino Adults
The Efficacy of Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota (LcS) on Relieving Constipation-Related Symptoms of Filipino Adults
University of Santo Tomas
60 participants
Oct 1, 2025
INTERVENTIONAL
Conditions
Summary
The primary purpose of this study is to investigate whether the consumption of a probiotic drink (with Lacticaseibacillus paracasei strain Shirota (LcS)) relieves constipation-related symptoms of Filipino adults, specifically its effect on stool consistency, frequency, and duration, and on gastrointestinal discomfort.
Eligibility
Inclusion Criteria3
- Filipino adult male or female aged 18 to 59 years old
- Apparently healthy adults with constipation-related symptoms of hard to lumpy stools (Bristol Stool Form Scale 1-2) in 25% or more of defecations in a week
- With cold storage at home
Exclusion Criteria12
- Habitual intake of food items containing probiotics and prebiotics as food supplements (previous 3 months, at least three times per week)
- Constipation due to organic or neurologic origin
- High fiber intake (\>30 g/day)
- Pregnant or lactating
- Allergy to dairy products and/or lactose intolerance
- Use of laxatives, anticholinergics and medications for constipation or diarrhea within the past three months
- Use of antibiotics within the past two weeks
- Presence of chronic diseases such as diabetes mellitus and its complications, cardiovascular diseases, kidney problems
- GI condition that may interfere with the evaluation of the outcome such as hemorrhoids, intestinal obstruction and inflammatory bowel diseases
- Recent history of any gastrointestinal surgery
- Have pre-existing medical conditions like hypo- or hyperthyroidism and congenital abnormalities
- Participation in another study with test product two months prior the study
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Interventions
Probiotic drink with LcS will be consumed once per day for four weeks
Brochure containing recommendations to improve constipation will be provided at end of study.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07083596