RecruitingPhase 4NCT07084402

Short-term Bactericidal Effect of Contezolid in MAC-PD

Short-term Bactericidal Effect of Contezolid in Mycobacterium Avium Complex Pulmonary Disease


Sponsor

Bin Cao

Enrollment

188 participants

Start Date

Jul 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if contezolid works to treat mycobacterium avium complex pulmonary disease in adults. It will also learn about the safety of contezolid. The main questions it aims to answer are: Does adding contezolid to standard regimen further decrease the bacterial load in patients' sputum compared with current standard regimen? What medical problems do participants have when taking contezolid along with standard regimen? Researchers will compare standard regimen plus contezolid to standard regimen alone to see if contezolid helps further lower the count of bacteria in patients' sputum. Participants will: Take contezolid and standard regimen (azithromycin, ethambutol and rifampicin) or standard regimen only for 6 months, contezolid is administered every day while other drugs are taken 3 times a week Visit the clinic once every 1 month for checkups and tests.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Azithromcyin, a drug called Contezolid, and others for people with mycobacterium avium complex pulmonary disease. The study is currently recruiting participants at 3 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGContezolid

contezolid 800mg po q12h for 6 months

DRUGAzithromcyin

azithromycin 500mg po tiw (250mg po tiw if weight below 50kg) for 6 months.

DRUGRifampicin (RIF)

rifampicin 600mg po tiw for 6 months.

DRUGEthambutol

ethambutol 25mg/kg po tiw for 6 months.


Locations(3)

Beijing Chest Hospital, Capital Medical University

Beijing, Beijing Municipality, China

China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

Jiangxi Provincial Chest Hospital

Nanchang, Jiangxi, China

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NCT07084402


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