RecruitingPhase 4NCT07213765

Short-term Antibiotic Therapy in Mycobacterium Avium Complex Pulmonary Disease


Sponsor

Bin Cao

Enrollment

188 participants

Start Date

Jul 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if adding contezolid works to shorten the length of treatment in mycobacterium avium pulmonary disease in adults. It will also learn about the safety of extended usage of contezolid. The main questions it aims to answer are: Does adding contezolid to standard regimen decrease the bacterial load, lesion severity and improve the life quality of patients with mycobacterium avium pulmonary disease? What medical problems do participants have when taking contezolid for an extended length? Researchers will compare standard regimen plus contezolid to standard regimen alone to see if contezolid helps further decrease the bacterial load, lesion severity and improve the life quality of patients with mycobacterium avium pulmonary disease? Participants will: Take contezolid and standard regimen (azithromycin, ethambutol, and rifampicin) for 6 months, contezolid is administered every day while other drugs are taken three times a week OR take standard regimen three times a week for 12 months. Visit the clinic once every 1 month for checkups and tests.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Azithromycin, a drug called Azithromycin, and others for people with mycobacterium avium complex pulmonary disease. The study is currently recruiting participants at 6 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGContezolid

contezolid 800mg po q12h\*6m

DRUGAzithromycin

azithromycin 500mg po tiw (250mg po tiw for BW under 50kg)\*6m

DRUGAzithromycin

azithromycin 500mg po tiw (250mg po tiw for BW under 50kg)\*12m

DRUGEthambutol (E)

ethambutol 25mg/kg po tiw\*6m

DRUGEthambutol (E)

ethambutol 25mg/kg po tiw\*12m

DRUGRifampicin (R)

rifampicin 600mg po tiw (450mg po tiw for BW under 50kg)\*6m

DRUGRifampicin (R)

rifampicin 600mg po tiw (450mg po tiw for BW under 50kg)\*12m


Locations(6)

Anhui Chest Hospital

Hefei, Anhui, China

Beijing Chest Hospital, Capital Medical University

Beijing, Beijing Municipality, China

China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

Guangzhou Chest Hospital

Guangzhou, Guangdong, China

Jiangxi Chest Hospital

Nanchang, Jiangxi, China

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

View Full Details on ClinicalTrials.gov

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NCT07213765


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