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RecruitingNCT07085247

The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease

The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease and the Clinical Effect of Microdiscectomy

Sponsor

Masaryk University

Enrollment

400 participants

Start Date

Jun 1, 2025

Study Type

OBSERVATIONAL

Conditions

Low Back PainLumbar Disc HerniationLumbar Disc DegenerationCutibacterium Acnes

Summary

The goal of this study is to clarify the role of the bacterium Cutibacterium acnes in the development of degenerative disc disease in patients with lumbar disc herniation who underwent microdiscectomy as part of their regular medical care.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • minimum age of 18 years
  • MRI of the lumbosacral spine performed one month ± 2weeks before surgery showing a disc protrusion, herniation, or free nucleus pulposus sequestration
  • matching physical examination findings including positive straight leg raise test, dermatomal sensory deficits, myotome motor deficits, and diminished deep tendon reflexes.

Exclusion Criteria7

  • antibiotics or corticosteroid use the month before surgery
  • ongoing bacterial or viral infection
  • immunocompromised patient
  • trauma
  • undefined radiological mass
  • inflammatory arthritis
  • other rheumatologic diseases.

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Locations(1)

St. Anne´s University Hospital Brno

Brno, Czechia

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NCT07085247

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