RecruitingNot ApplicableNCT07087873

Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases


Sponsor

Xuanwu Hospital, Beijing

Enrollment

128 participants

Start Date

May 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations. It also evaluates the effectiveness of transcranial electrical stimulation in alleviating clinical symptoms of IIDDs patients, and analyzes the key factors affecting the treatment efficacy. By uncovering the overall and individual characteristics of IIDDs, this study seeks to enhance therapeutic outcomes through personalized neuromodulation programs. The findings will provide a basis for applying non-invasive brain stimulation (NIBS) in IIDDs treatment and offer new ideas for future personalized medicine approaches.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study tests a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) to see if it can improve thinking and memory problems in people with inflammatory brain diseases such as multiple sclerosis or neuromyelitis optica spectrum disorder. **You may be eligible if...** - You are 18–60 years old - You have been diagnosed with multiple sclerosis, neuromyelitis optica spectrum disorder, or another central nervous system inflammatory demyelinating disease - Your medications have been stable for at least 3 months - You have measurable cognitive (thinking/memory) difficulties **You may NOT be eligible if...** - You have metal implants in your skull or a pacemaker - You have a history of epilepsy or seizures - You are pregnant - You have significant uncontrolled psychiatric conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICENeuroelectrical modulation group

Participants received transcranial electrical stimulation using the Spanish Neuroelectrics StarStim 32 device.

DEVICEPseudo-neuromodulation group

Pseudo-stimulation is performed using the same equipment and procedures as in the neuromodulation group.


Locations(1)

Xuanwu Hospital, Capital Medical University

Beijing, Beijing Municipality, China

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NCT07087873


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