RecruitingNot ApplicableNCT07087951

Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)

Development and Validation of an Innovative Gamma Auditory Stimulation System for Older Adults With Cognitive Decline: A Randomized, Double-blind, Placebo-controlled Study (Study 1)

Sponsor

Chang Gung Memorial Hospital

Enrollment

70 participants

Start Date

Nov 14, 2025

Study Type

INTERVENTIONAL

Conditions

Cognitive Dysfunction EEG Brain Oscillations Alzheimer's Disease (AD) and Related Disorders

Summary

Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.

Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Gamma auditory stimulation device (active setting) and Gamma auditory stimulation device (sham setting) for people with alzheimer's disease (ad) and related disorders, cognitive dysfunction, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 60 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEGamma auditory stimulation device (active setting)

Participants will receive auditory stimulation using the gamma auditory stimulation device (active setting) for 1 hour per day, 5 days a week, over 12 weeks, for a total of 60 hours.

DEVICEGamma auditory stimulation device (sham setting)

Participants will receive auditory stimulation using the gamma auditory stimulation device (sham setting) for 1 hour per day, 5 days a week, over 12 weeks, for a total of 60 hours.