RecruitingPhase 3NCT07092566

R.E.C.K vs Exparel in Robotic Nephrectomy

Efficacy of Ropivacaine Epinephrine Clonidine Ketorolac (R.E.C.K) vs Exparel in Robotic Nephrectomy: a Randomized, Prospective Trial

Sponsor

Wake Forest University Health Sciences

Enrollment

170 participants

Start Date

Nov 14, 2025

Study Type

INTERVENTIONAL

Conditions

Pain Management Renal Carcinoma Nephrectomy / Methods

Summary

The purpose of the study is to evaluate the efficacy of R.E.C.K (ropivacaine epinephrine clonidine ketorolac) vs Exparel during robotic partial and radical nephrectomy in a single institution, prospective, randomized trial. The study will evaluate post operative Numerical Rating Score (NRS) pain scores, post operative pain medication intake (opioids and over-the-counter pain medicines) and length of stay across the two patient cohorts. The findings will help to inform whether the increased cost of Exparel when compared to R.E.C.K is justified.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study compares two approaches to pain control after robotic kidney removal surgery (nephrectomy): R.E.C.K (a regional nerve block technique) versus Exparel (a long-acting local anesthetic injection). The goal is to determine which approach provides better pain relief with fewer opioids. **You may be eligible if...** - You are 18 or older - You are scheduled for robotic partial or radical nephrectomy (kidney removal surgery) - You can provide informed consent **You may NOT be eligible if...** - You have been using opioid pain medications regularly within the past 30 days - You are pregnant - The surgeon determines you are not a suitable candidate for either R.E.C.K or Exparel Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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