Clinical Study of U01（ssCART-19） in Patients With B-Cell Lymphoma

This study is testing a new type of cell therapy called ssCART-19 (U01) for people with B-cell lymphoma (a type of blood cancer) whose cancer has come back or stopped responding to standard treatments. CAR-T therapy involves taking a patient's own immune cells, engineering them to recognize and attack cancer, and then putting them back into the body. **You may be eligible if...** - You are aged 2 to 75 years old - You have been diagnosed with B-cell lymphoma that has relapsed or not responded after at least two prior treatments - Your tumor cells test positive for a protein called CD19 - You have at least one measurable area of cancer - Your heart, lungs, liver, and kidneys are working adequately - You have a life expectancy of more than 3 months **You may NOT be eligible if...** - You have another active cancer - You have active hepatitis B, hepatitis C, HIV, or syphilis - You have an uncontrolled serious infection - You have significant uncontrolled heart problems (e.g., recent heart attack, very low heart pumping function) - You are pregnant or breastfeeding - You have an active autoimmune condition requiring immune-suppressing medications Talk to your doctor to see if this trial is right for you.