RecruitingNot ApplicableNCT07094100

Tissue Engineered Cartilage to Repairing Articular Cartilage Defects

Clinical Study of Cartilage Constructed by Autologous Bone Marrow Mesenchymal Stem Cells in Repairing Articular Cartilage Defects

Sponsor

The First Affiliated Hospital of Xinxiang Medical College

Enrollment

30 participants

Start Date

Apr 20, 2026

Study Type

INTERVENTIONAL

Conditions

Cartilage Injury OA Knee

Summary

The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

The patients' age ranges from 18 to 65 years old, and gender is not restricted;
The imaging results show that the epiphyseal growth is mature;
The defects or localized injuries of joint cartilage caused by trauma or other reasons;
The injured area is the distal weight-bearing surface of the femoral condyle of the knee joint, with no more than 4 lesions, and there is no injury to the cruciate ligaments;
The patients voluntarily sign and provide a written informed consent form and are willing to closely cooperate with the doctor's strict postoperative rehabilitation program.

Exclusion Criteria12

The patient is extremely overweight, with a body mass index greater than 35;
The lower limb alignment is valgus by more than 10° and varus by more than 5°;
Multiple ligament injuries;
There are numerous bad habits such as heavy smoking, drug abuse, and excessive alcohol consumption;
Has undergone open knee joint surgery within the past six months;
Has severe joint stiffness or fibrosis;
Has an allergic constitution or a history of allergic reactions to collagen;
Has mental abnormalities;
Cannot or is unwilling to undergo rehabilitation training;
Has primary cardiovascular diseases, lung diseases, endocrine and metabolic disorders, or other serious diseases that affect their daily life, such as tumors or AIDS;
Pregnant or lactating women, or those planning to conceive during the trial period;
Other acute or chronic diseases, for which the researchers consider surgery to be inappropriate.