Efficacy and Safety of Nalfurafine Hydrochloride ODT for Moderate-to-Severe Pruritus in Patients on Peritoneal Dialysis

This study is testing a medication called nalfurafine hydrochloride (a dissolvable tablet) for people on peritoneal dialysis — a type of home kidney dialysis — who suffer from moderate to severe, persistent itching. Itching is an extremely common and distressing problem for people with kidney failure, and this drug works on a different pathway than standard antihistamines. **You may be eligible if...** - You are aged 18–85 - You have been on peritoneal dialysis for at least 3 months - You have moderate to severe itching that has not responded well to other treatments - Your itching severity scores are consistently high during the study baseline period **You may NOT be eligible if...** - You plan to switch to hemodialysis or get a kidney transplant during the study - You have severe liver problems - Your itching is caused by something other than kidney disease (such as an allergy or skin infection) - You have severe heart failure or a recent heart attack - You are pregnant or breastfeeding - You have a psychiatric condition or substance use disorder - You have taken opioid medications within the past 2 weeks - You have been in another clinical trial within the past 28 days Talk to your doctor to see if this trial is right for you.