Comparison of Four-Channel Functional Electrical Stimulation vs. One-Channel Electrical Stimulation on Moderate Arm/Hand Paresis in Subacute Stroke Patients
Efficacy of EMG-triggered Four-Channel Functional Electrical Stimulation vs. Cyclic One-Channel Electrical Stimulation on Moderate Arm/Hand Paresis in Subacute Stroke Patients. A Randomized Controlled Single Blinded Multicenter Study
MED-EL Elektromedizinische Geräte GesmbH
44 participants
Jul 14, 2025
INTERVENTIONAL
Conditions
Summary
This study will compare two treatments that may help participants recover after having suffered from stroke. Persons who experience weakness or paralysis of their arms/hands will be randomly placed in one of two groups. Each receives treatment five times a week for three weeks. One group will be treated with electrostimulation following a cyclic pattern (control treatment), the other group will be treated with electrostimulation triggered by nerve signals (i.e. stimulation starts when they deliberately try to move their arm (investigational treatment). Before and after the three weeks and additionally 12 weeks later, the ability to move the arm and hand will be documented with standardized tests.
Eligibility
Inclusion Criteria17
- First-time ischemic stroke with moderate arm paresis (Motricity Index - UE Sum-Score ≥ 40 ≤ 77 points) (Collin \& Wade, 1990)
- Early to late subacute phase (7 days - 6 months) (Bernhardt et al., 2017)
- Existing ADL ability before the event (ICF d5 self-care, d6 domestic life, extent of problem ≤1 points) (WHO, 2001)
- Age ≥18 - 99 years
- Signed and dated ICF before the start of any study-specific procedure.
- Implanted defibrillators, brain stimulators, pacemakers, medication pumps
- Therapy-resistant epilepsy
- Fever or infectious diseases
- Inflammatory or tumorous skin diseases in the stimulation area,
- Thromboses or vein inflammations
- Severe contractures of the affected extremity
- Wounds in the stimulation area
- Pregnancy
- Known allergic reactions to components of the investigational medical device
- Unstable psychological status
- Participation in other pharmacological clinical investigations within four weeks prior to enrolment
- Anything that, in the opinion of the Investigator, would place the subject at increased risk or preclude the subject's full compliance with or completion of the study
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Interventions
Cyclic single channel neuromuscular stimulation is used to trigger repetitive muscular contractions
EMG-MES provides biofeedback by using electromyographic signals to trigger muscular contractions
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT07098572