Preoperative Acetazolamide
Preoperative Acetazolamide for Improved Pain Control Following Laparoscopic Hysterectomy
Prisma Health-Upstate
100 participants
Oct 30, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.
Eligibility
Inclusion Criteria4
- Women
- Ages 21-65
- undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy
- undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy
Exclusion Criteria16
- Allergy to acetazolamide or sulfonamides
- Known electrolyte disturbances
- Pregnancy
- Kidney failure or creatinine \>1.5
- Diuretic or lithium use
- Chronic obstructive pulmonary disease (COPD) or other lung disease
- Central nervous system disorders
- Liver disease
- Glaucoma
- Preoperative or chronic opioid use
- Diagnosis of fibromyalgia
- Preoperative shoulder pain
- Conversion to laparotomy
- Intraoperative bladder or bowel injury
- Inability to understand or utilize visual analog scale
- Undergoing concurrent reconstructive procedures
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Interventions
Active Drug
Inactive Drug
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07101250