RecruitingNCT07104214

Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gastroscopy

Development and Validation of a Risk Prediction Model for Gastric Retention in Patients Undergoing Sedated Gastroscopy: a Multicentre Prospective Cohort Study


Sponsor

Zhejiang University

Enrollment

5,000 participants

Start Date

Aug 3, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Gastric retention not only compromises the quality of endoscopic examination but also significantly increases the risk of reflux and aspiration in sedated patients. Aspiration of gastric contents represents a critical anesthesia-related complication during the perioperative period, carrying substantial implications for anesthetic management. With the growing volume of sedated gastroscopy procedures, predicting gastric retention has become an urgent clinical priority. This prospective study aims to establish a standardized gastric residual volume (GRV) grading system to evaluate both the volume of retained gastric contents and its contributing factors in patients undergoing upper gastrointestinal endoscopy. We will systematically assess the impact of demographic characteristics, comorbidities, and medication history on gastric emptying function. This study will facilitate establishment of an endoscopy-based simplified assessment system for gastric retention.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Age ≥18 years.
  • Patients scheduled for elective sedated gastroscopy or sedated gastro-colonoscopy.
  • Participant provides informed consent.

Exclusion Criteria4

  • Acute upper gastrointestinal bleeding (active hematemesis, melena, or confirmed UGIB within 24h).
  • Emergency endoscopic procedures
  • Known pregnancy or lactation
  • Subjects deemed ineligible by investigators

Locations(3)

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

The Second Affiliated Hospital of Jiaxing University

Jiaxing, Zhejiang, China

The Fifth Affiliated Hospital of Wenzhou Medical University

Lishui, Zhejiang, China

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NCT07104214


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