RecruitingNot ApplicableNCT07105345

Exploring Efficacy of Multi-Mode Cognitive Processing Therapy (CPT) for PTSD

Efficacy of Multi-Modal Cognitive Processing Therapy for PTSD: A Longitudinal, Multicenter, Single-Blind RCT on Symptoms, Sleep, Anxiety, Depression, Remission, and Posttraumatic Growth

Sponsor

Far Eastern Memorial Hospital

Enrollment

60 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Posttraumatic Stress Disorder

Summary

This study is a longitudinal, multicenter, single-blind, two-arm randomized controlled trial designed to evaluate the effectiveness of Multi-Modal Cognitive Processing Therapy (MMCPT) for individuals with posttraumatic stress disorder (PTSD). Participants will be randomly assigned to either the intervention group receiving MMCPT or a control group receiving treatment-as-usual (TAU). The intervention follows the standard CPT manual developed by Resick and consists of twelve weekly 90-minute individual sessions. The primary outcomes include PTSD symptom severity assessed by the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) and the PTSD Checklist for DSM-5 (PCL-5). Secondary outcomes include sleep quality (actigraphy, PSQI), anxiety (STAI), depression (HDRS-17), remission rate, and posttraumatic growth (PTGI). Assessments will occur at baseline, mid-treatment, post-treatment, and at 3-, 6-, 9-, and 12-month follow-ups.

Eligibility

Min Age: 20 YearsMax Age: 65 Years

Inclusion Criteria5

Aged between 20 and 65 years
Diagnosed with PTSD according to DSM-5 criteria
Score ≥ 33 on the PTSD Checklist for DSM-5 (PCL-5)
Able to provide informed consent
Stable psychiatric medication regimen (if any) for at least 4 weeks prior to enrollment

Exclusion Criteria5

Diagnosed with schizophrenia, schizoaffective disorder, or bipolar I disorder
Current substance dependence or abuse within the past 6 months
Severe suicidal ideation or suicide attempt in the past 6 months
Cognitive impairment or neurological disorder affecting participation
Concurrent participation in other psychological treatment for PTSD

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Interventions

BEHAVIORALCognitive Processing Therapy (CPT)

Participants will receive 12 weekly 90-minute individual sessions of Cognitive Processing Therapy (CPT) following the Resick manual. The intervention includes cognitive restructuring, trauma-related belief processing, and structured behavioral assignments. Sessions are delivered by trained therapists.

OTHERTreatment as Usual (TAU)

Participants will receive routine outpatient psychiatric care as determined by clinicians. This may include medication, general supportive therapy, or psychoeducation, but will not include structured CPT sessions.