RecruitingPhase 1NCT07106827

A Study of GV20-0251 in Advanced or Refractory Solid Tumors

Single Arm Clinical Study Protocol of GV20-0251 in the Treatment of Advanced/Refractory Solid Tumors


Sponsor

West China Hospital

Enrollment

10 participants

Start Date

Sep 4, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm, single-center study for multiple tumor indications to evaluate the safety of GV20-0251. The trial uses a 3 + 3 design and enrolls 3-6 patients in the 10 mg/kg and 20 mg/kg dose groups, respectively. The cancer types include solid tumors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new experimental drug called GV20-0251 in people with advanced or refractory solid tumors (cancers that have spread or stopped responding to standard treatments). This is an early-phase trial focused on finding the right dose and evaluating safety. **You may be eligible if:** - You are 18 or older - You have a confirmed advanced solid tumor that has progressed despite standard treatment - You have already tried standard therapies and they have failed or you cannot tolerate them - Your overall health is good (ECOG 0–1) - You have been cancer-free from any other cancer for at least 2 years - You are willing to use contraception if applicable **You may NOT be eligible if:** - You have acute leukemia - You have certain other active cancers - You have serious uncontrolled health conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGGV20-0251

Increasing doses of GV20-0251 administered by intravenous (IV) infusion once every 3 weeks


Locations(1)

West China Hospital

Chengdu, Sichuan, China

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NCT07106827


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