RecruitingNot ApplicableNCT07109739

Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function


Sponsor

University of Minnesota

Enrollment

144 participants

Start Date

Oct 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a breathing exercise called Inspiratory Muscle Strength Training (IMST) — where you breathe in forcefully against resistance — can lower blood pressure and improve blood vessel health. Researchers want to find the right dose of this exercise. **You may be eligible if...** - You are 18 years or older - Your resting systolic blood pressure (the top number) is 120 mmHg or higher - You do not have serious heart or metabolic disease - You speak English and can follow study instructions - You are a non-smoker (no cigarettes or vaping in the past year) - You can follow pre-visit rules (no caffeine or food for 3 hours, no alcohol or vigorous exercise for 24 hours before visits) **You may NOT be eligible if...** - You have a history of cardiovascular disease - You recently had abdominal surgery or have an abdominal hernia - You have severe or hard-to-detect asthma - You have a ruptured eardrum or ear condition - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEPOWERbreathe K5

The POWERbreathe K5 is portable, battery-powered, and commercially available. No modifications to the FDA-approved design are being made. Its use in this study is consistent with prior published human research and does not constitute a significant deviation from labeled use in terms of safety or function.


Locations(1)

University of Minnesota

Minneapolis, Minnesota, United States

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NCT07109739


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