RecruitingNot ApplicableNCT07111637

Artificial Intelligence-Assisted Magnetic Resonance Imaging for Quality, Efficiency and Equity in the National Health Service (NHS) Care of Multiple Sclerosis


Sponsor

Queen Mary University of London

Enrollment

1,336 participants

Start Date

Jun 14, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Multiple Sclerosis (MS) is a long-term disease that affects over 150,000 people in the UK. Starting treatment early is important for managing Multiple Sclerosis (MS). It is also essential to monitor the treatment to see if it is working and to switch treatments if needed. Magnetic resonance imaging (MRI) is the only accepted tool to monitor how well the treatment is working. Current evaluation of brain Magnetic resonance imaging (MRI) scans requires visual inspection, of which sensitivity is degraded by human, and technical factors, such as lack of time, fatigue of radiologists, and lack of standardization of image acquisition protocols across the National Health Service (NHS). MRI-readings can be significantly enhanced by artificial intelligence (AI)-assistive software. Evidence suggests the rate of new lesion detection to be 3 - 4 times higher when using assistive software compared to visual inspection of MRI scans. In this study, an Artificial Intelligence (AI) software called "icobrain ms." developed by the company "icometrix" (Leuven, Belgium) is tested. This tool helps track MS by measuring changes in the brain using MRI scans. The AI can highlight problem areas and create reports that doctors can use to make better decisions about participants' treatment. The aim of the study is to prove that icobrain ms can be used to assist the neuro-radiologist with their visual assessment of MRI scans by a radiologist, and that it will help clinicians make more informed decisions about participants' current MS treatment.


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is developing and testing an AI-powered platform to help manage multiple sclerosis (MS) through smarter use of MRI brain scans. The system aims to automatically detect and measure MS-related changes in the brain, reducing the time radiologists spend reviewing scans and giving patients better access to their own data through a digital app. **You may be eligible if...** - You have had a clinically isolated syndrome (a first neurological episode that may be an early sign of MS) or have a confirmed diagnosis of MS - You are scheduled for a routine MRI brain scan as part of your MS care - You are currently receiving a disease-modifying therapy (a medication to slow MS progression) - You have access to a smartphone, tablet, or computer **You may NOT be eligible if...** - You are currently enrolled in a randomized controlled clinical drug trial for MS (though participation in a single-arm study may still be allowed, depending on circumstances) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEAI software

icobrain ms is an Artificial Intelligence (AI)-assistive software which quantifies brain Magnetic Resonance Imaging (MRIs) and summarises clinically relevant findings for patients with Multiple Sclerosis in structured electronic radiological reports and annotated images.


Locations(1)

Barts Health NHS Trust

London, United Kingdom

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NCT07111637


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