Pressure-Volume Loop Assessment in Valvular Heart Disease

This study is using a specialized heart monitoring technique called pressure-volume loop analysis (a way to measure how the heart chambers fill and pump with each beat) to better understand heart function in people with severe valve disease. This information helps doctors make better decisions about treatment, including surgery or catheter-based procedures. **You may be eligible if...** - You are 18 years or older - You have severe structural heart disease, specifically one of: moderate-to-severe or severe mitral valve regurgitation (leaking mitral valve) with heart failure, at least severe tricuspid valve regurgitation (leaking tricuspid valve), or significant pulmonary valve disease (narrowing and/or leaking) **You may NOT be eligible if...** - You are under legal guardianship or protection - You are pregnant or breastfeeding - You have conditions that make right heart catheterization unsafe, such as blockage of the main veins, mobile clots in the right heart, or severe tricuspid valve narrowing (stenosis) Talk to your doctor to see if this trial is right for you.