RecruitingNot ApplicableNCT07115563

Daily Amino Acid Supplementation for People With Parkinson's Disease

Effects of Targeted Amino Acid Supplementation for People With Parkinson's Disease on Amino Acid Profiles and Health Related Markers


Sponsor

Cristina Colon-Semenza

Enrollment

30 participants

Start Date

Oct 31, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function. The main questions it aims to answer are: Does the tailored amino acid supplement increase essential amino acids (nutritional status)? Does the tailored amino acid supplement increase an antioxidant (complex amino acid) and decrease an amino acid associated with oxidative stress? Does the tailored amino acid supplement improve physical and mental health compared to a placebo supplement? Researchers will compare the tailored amino acid supplement to a placebo (a look-alike substance that contains no active ingredients) to see if the tailored amino acid supplements work to support health for people with Parkinson's disease. Participants will: Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake.


Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a daily amino acid supplement can improve motor symptoms, mood, or quality of life in people with Parkinson's disease who take dopamine replacement medication. Amino acids are the building blocks of proteins and may support how dopamine is produced and used in the brain. **You may be eligible if...** - You are 60–80 years old - You have been diagnosed with idiopathic Parkinson's disease - You have been on dopamine replacement medication (such as levodopa) for at least 2 years - Your medication dose has been stable for at least 3 months **You may NOT be eligible if...** - You have significant cognitive impairment - You have been diagnosed with atypical Parkinson's or a different form of Parkinsonism - You take a dopamine-blocking drug - You use deep brain stimulation (DBS) - You have a bleeding disorder or take blood thinners - You have had stomach or bowel removal surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTTargeted Amino Acid Supplement

Blend of the essential amino acids (Leucine \& Tryptophan), a conditionally essential amino acids (Arginine \& Taurine), and non-essential amino acids (Glutamate \& Tyrosine) designed to meet the unique nutritional needs of people with Parkinson's disease (PD).

DIETARY_SUPPLEMENTControl (placebo)

The inert amino acid (alanine) will serve as an isonitrogenous control.


Locations(1)

University of Connecticut

Storrs, Connecticut, United States

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NCT07115563


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