Integrating HIV Prevention With TB Household Contact Evaluation in Uganda
Integrating HIV Prevention With TB Household Contact Evaluation in Uganda (TB PrEP)
University of Washington
2,480 participants
Dec 10, 2025
INTERVENTIONAL
Conditions
Summary
This household randomized implementation study assesses the implementation and effectiveness of home-based HIV self- testing and PrEP initiation versus standard clinic referral for PrEP initiation during modified standard-of-care (modified SOC) household TB contact investigation in Uganda. It uses qualitative methods to evaluate the process of implementing the intervention and a health economic evaluation to assess the financial sustainability of this strategy.
Eligibility
Inclusion Criteria4
- Person with pulmonary TB OR live in a household with someone with pulmonary TB being treated at one of the participating health facilities
- Household includes ≥2 persons
- Age 15 years and older
- Willingness to participate in study procedures
Exclusion Criteria3
- Lives in a congregate setting (e.g., dormitory or jail)
- Lives outside the study area
- Any other condition that, in the opinion of the Investigator/designee, could preclude informed consent, make study participation unsafe, or otherwise interfere with achieving study objectives
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Interventions
Integration of HIV self-testing into TB household contact investigation
Integration of PrEP initiation into TB household contact investigation
Locations(1)
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NCT07119359