Ketogenic Intervention for Bipolar Depression

This study is testing whether a ketogenic (high-fat, very low-carbohydrate) diet can help reduce depression in people with bipolar disorder who are already on mood-stabilizing medication. **You may be eligible if...** - You are 18–50 years old - You have a diagnosis of bipolar I, bipolar II, or bipolar schizoaffective disorder - You are currently experiencing at least mild depression - You have been on stable mood-stabilizing medication for at least 2 weeks - You are willing to switch to a ketogenic diet - You are not pregnant and using birth control if sexually active **You may NOT be eligible if...** - You have Type 1 diabetes, kidney failure, pancreatitis, or are on dialysis - You have active suicidal thoughts or plans - You have a current drug or alcohol use disorder - You have a history of heart disease, stroke, or significant cardiovascular problems - You have severe liver disease or significant osteopenia/osteoporosis - You are already in a ketogenic state or on medications that cause acidosis (e.g., topiramate) - You have a rare fat metabolism disorder Talk to your doctor to see if this trial is right for you.