RecruitingNot ApplicableNCT07122336
Optimized Ablation of the Posterior Wall in Persistent Atrial Fibrillation
Sponsor
Shanghai Chest Hospital
Enrollment
384 participants
Start Date
Jul 16, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The design of this study is an intervention, randomized, controlled study and contains three randomized groups：（1）PVI group；（2）PVI+PWI group;（3）PVI+PWI+EGM group.
Eligibility
Min Age: 18 YearsMax Age: 80 Years
Inclusion Criteria7
- Age ≥18 years
- First-time ablation for persistent atrial fibrillation (PsAF)
- Persistent AF definition: Sustained episodes lasting ≥7 days but ≤3 years (including episodes requiring pharmacologic or electrical cardioversion after ≥7 days)
- Symptomatic AF with intolerance to at least one antiarrhythmic drug (AAD)
- Documented PsAF episode: At least one recorded PsAF episode within the last 2 years prior to enrollment, confirmed by: ECG,Holter monitorin, Loop recorder, Telemetry, Transtelephonic monitoring (TTM),Implantable device
- Ability and willingness to provide written informed consent
- Compliance with all study follow-up requirements
Exclusion Criteria8
- Paroxysmal AF: Episodes lasting \<7 days (or requiring pharmacologic/electrical cardioversion \<7 days)
- Long-standing persistent AF: Continuous AF duration \>3 years
- No prior attempt/pursuit of cardioversion or sinus rhythm maintenance
- Contraindications to systemic anticoagulation
- Pregnancy
- Advanced renal or hepatic failure
- Severe valvular heart disease or cyanotic congenital heart disease
- Hypertrophic cardiomyopathy (HCM)
Interventions
PROCEDUREPVI
PVI
PROCEDUREPWI
PWI
PROCEDUREEGM
EGM
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07122336
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