RecruitingNCT07125352

Neutrophil to Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Neutrophil to Lymphocyte Ratio in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Marker of Severity and Prognosis

Sponsor

Ain Shams University

Enrollment

190 participants

Start Date

May 20, 2025

Study Type

OBSERVATIONAL

Conditions

Chronic Obstructive Pulmonary Disease Exacerbation

Summary

Chronic obstructive pulmonary disease (COPD) stands as one of the leading causes of mortality worldwide. Acute exacerbations of COPD (AECOPD) lead to rapid respiratory function decline and worsened disease status. Despite recent studies, the ability of the neutrophil-to-lymphocyte ratio (NLR) to predict outcomes in patients with COPD remains controversial. It remains controversial whether NLR can predict clinical outcomes in hospitalized patients with AECOPD. Therefore, this study was conducted to investigate the predictive value of NLR for severity, adverse outcomes in hospitalized patients with AECOPD, and predicting treatment response in patients with AECOPD

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study is investigating whether a simple blood test measurement called the neutrophil-to-lymphocyte ratio (NLR) — the ratio of two types of white blood cells — can predict how serious a COPD flare-up (acute exacerbation) will be. **You may be eligible if...** - You are 18 years or older - You have been admitted to the chest department at Ain-Shams University Hospitals - You have been diagnosed with an acute exacerbation of COPD based on the 2024 GOLD guidelines **You may NOT be eligible if...** - You have refused treatment - You have COPD alongside cancer, blood disorders (hematological conditions), or other conditions that would affect white blood cell counts Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERneutrophil lymphocyte ratio in COPD patients

Neutrophil lymphocyte ratio in determining severity and prognosis in exacerbation of COPD patients

Locations(1)

Ain Shams University

Cairo, Abbasyea, Egypt

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