RecruitingNCT07131670

Symptoms Burden in Lung Cancer Patients Undergoing Definitive Chemoradiotherapy: Insights From Electronic Patient-Reported Outcomes

A Prospective Observational Study on Symptom Burden in Lung Cancer Patients Undergoing Definitive Chemoradiotherapy: Insights From Electronic Patient-Reported Outcomes


Sponsor

Qian Chu

Enrollment

100 participants

Start Date

Jun 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This prospective observational study aims to evaluate symptom burden and symptom clusters among lung cancer patients undergoing definitive concurrent chemoradiotherapy (CRT), based on electronic patient-reported outcomes (ePROs). Patients will complete the validated MDASI-LC and EQ-5D instruments weekly from baseline through the end of CRT and for 12 weeks post-treatment. The study will characterize the longitudinal trajectories of symptom severity and interference, identify distinct symptom clusters and their temporal patterns, and explore patient-level predictors of symptom burden. The findings may support the development of personalized symptom management strategies and improve quality of life during and after CRT.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is tracking the symptom burden — meaning how much symptoms affect daily life — in people with lung cancer who are undergoing definitive chemoradiotherapy (a combination of chemotherapy and radiation as a main treatment). Participants fill out electronic questionnaires throughout their treatment. **You may be eligible if...** - You have unresectable (inoperable) stage III non-small cell lung cancer, or limited-stage small cell lung cancer - You are 18 or older - You are currently receiving chemoradiotherapy as your primary treatment - You are able and willing to complete electronic questionnaires **You may NOT be eligible if...** - You have severe heart, liver, or kidney problems - You have a psychiatric illness or significant cognitive impairment that would prevent you from completing questionnaires - You have previously had radiation to the chest or middle of the chest Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERElectronic Patient-Reported Outcome Monitoring

Participants complete the MDASI-LC and EQ-5D questionnaires electronically on a weekly basis during CRT and for 12 weeks after CRT. The data are used to evaluate symptom burden, symptom clusters, and symptom trajectories.


Locations(1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

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NCT07131670


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