RecruitingPhase 2NCT07132918

HEARTS Trial for Thoracic Cancers

The cARdiac Radiation Therapy Sparing (HEARTS) for Thoracic Cancers


Sponsor

University of Wisconsin, Madison

Enrollment

60 participants

Start Date

Oct 8, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare a new way of using magnetic resonance-guided adaptive radiation therapy (MRgART) to the standard of care linear accelerator (LINAC) radiation treatment in people with cancer in the thoracic region near the heart. The main question it aims to answer is whether MRgART affects the heart differently than LINAC. Participants will: * Receive radiation therapy * Undergo MRIs and bloodwork * Complete quality of life questionnaires


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

The HEARTS trial is testing whether a heart-sparing radiation technique can reduce heart-related side effects in patients with thoracic (chest) cancers — including lung cancer, esophageal cancer, and thymoma — who receive radiation therapy as part of their treatment. **You may be eligible if...** - You are over 18 years old - You have a thoracic cancer such as non-small cell lung cancer (stage IIB–IV, inoperable), limited-stage small cell lung cancer, esophageal or esophagogastric cancer, or thymoma/thymic carcinoma - Your radiation treatment plan shows that a meaningful portion of your heart would receive a significant dose of radiation (based on planning calculations) - Your diagnosis has been confirmed by tissue or cell sample **You may NOT be eligible if...** - Your heart would not receive significant radiation based on the treatment plan - You have conditions that would make this specialized radiation technique unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONMRgART

Magnetic Resonance-guided Adaptive Radiation Therapy (MRgART) is a form of MRgRT that incorporates daily adaptive planning, or making a new treatment plan each treatment, and real-time imaging during treatment delivery.

RADIATIONLINAC

Daily 3D x-ray scans will be obtained for radiation delivery to confirm tumor and organ at risk placement.


Locations(1)

University of Wisconsin - Madison

Madison, Wisconsin, United States

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NCT07132918