RecruitingNCT07135856

Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC

Comparative Analysis of Minimally Invasive and Open Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC: A Multicenter Retrospective Evaluation of Surgical Outcomes

Sponsor

Shanghai Chest Hospital

Enrollment

400 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Conditions

Lung Cancer Neoadjuvant Therapy

Summary

The goal of this observational, retrospective, multicenter cohort study is to evaluate the surgical and oncologic outcomes of sleeve lobectomy performed via minimally invasive (RATS/VATS) or open thoracotomy approaches in patients with non-small cell lung cancer (NSCLC) who have undergone neoadjuvant therapy, including chemotherapy, immunotherapy, or combination regimens. The main questions this study aims to answer are: * Does minimally invasive sleeve lobectomy result in comparable or improved perioperative and postoperative outcomes compared to open thoracotomy following neoadjuvant treatment in NSCLC? * Does surgical approach influence oncologic endpoints such as margin status, lymph node dissection, recurrence-free survival, and overall survival? This research addresses a critical gap in the thoracic oncology field by evaluating the safety, complexity, and efficacy of advanced surgical techniques in the context of evolving multimodal therapy paradigm. Findings may inform clinical decision-making and optimize patient selection in an era of increasing use of neoadjuvant strategies for resectable NSCLC.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting data on outcomes for people with non-small cell lung cancer (NSCLC) who have undergone a complex surgical procedure called sleeve lobectomy — where a section of the airway (bronchus) is removed and reconstructed — after receiving neoadjuvant therapy (treatment given before surgery to shrink the tumor). **You may be eligible if...** - You are 18 or older - You have confirmed non-small cell lung cancer - You had sleeve lobectomy surgery with the intent to cure - You received chemotherapy, immunotherapy, or targeted therapy before surgery (neoadjuvant treatment) - Complete medical records and at least 12 months of follow-up data (or up to the time of death) are available **You may NOT be eligible if...** - You had a less extensive lung removal (segmentectomy) or a full lung removal (pneumonectomy) - You did not receive any treatment before surgery - Your surgery was only for diagnostic purposes - Your records are incomplete or you were lost to follow-up - Your cancer had already spread beyond the chest (stage IV) at the time of surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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