RecruitingNot ApplicableNCT07138677
Safty and Efficacy of MCI Network Guided TMS for Early Alzheimer's Disease: A Randomized, Double-blind Trial
The Safty and Efficacy of Mild Cognitiive Impairment Network Guided Transcranial Magnetic Stimulations for Patients With Early Alzheimer's Disease (SENS-eAD): A Randomized, Double-blind Trial
Sponsor
Anhui Medical University
Enrollment
40 participants
Start Date
Jul 20, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
Estimate the safty and efficacy of personalized network neuronavigated transcranial magnetic stimulations in early Alzheimer's disease patients
Eligibility
Min Age: 45 YearsMax Age: 85 Years
Inclusion Criteria5
- Subject diagnosed as either mild cognitive impairment due to AD or mild AD dementia based on National Institute on Aging-Alzheimer's Association criteria.
- MMSE score 18-28.
- CDR score 0.5-1.
- On stable treatment with IAChE or memantine for at least 6 months.
- Literate in Han Chinese.
Exclusion Criteria8
- Recevied rTMS treatment in the past 3 months.
- Depression or other psychiatric disorders.
- History of head injury, stroke, epilepsy or other neurologic disease.
- Organic brain defects on T1 or T2 images.
- History of unexplained loss of consciousness.
- Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, or any implanted medical device that is incompatible with MRI.
- Family history of medication refractory epilepsy.
- History of substance abuse within the last 6 months.
Interventions
OTHERtranscranial magnetic stimulation
Neuronavigated Theta-Burst Transcranial Magnetic Stimulation
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07138677
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