RecruitingNot ApplicableNCT07138729

Research on the Application of 99mTc-TCR-FAPI SPECT Imaging in Rheumatoid Arthritis


Sponsor

Luo Yaping

Enrollment

20 participants

Start Date

May 10, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study proposes to evaluate 99mTc-CTR-FAPI SPECT imaging as a cost-effective, low-radiation, and widely accessible alternative to 68Ga-FAPI PET/CT for assessing synovial lesions in RA patients, aiming to validate its diagnostic consistency with both PET/CT and physical examinations while correlating imaging findings with clinical disease activity metrics to establish a practical tool for long-term RA monitoring.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of SPECT imaging scan using a tracer called 99mTc-TCR-FAPI to detect cancer spread in patients with various types of solid tumors. FAPI (fibroblast activation protein inhibitor) scans target proteins found around tumor cells that are not found in most normal tissues, potentially making them more accurate than standard scans. **You may be eligible if...** - You have been diagnosed with a solid tumor (such as lung, breast, stomach, or other cancers) - Your doctor recommends imaging to assess where the cancer has spread - You are able to undergo a SPECT scan **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have severe kidney problems - You have a known allergy to the tracer components - You are unable to cooperate with the imaging procedure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TEST68Ga-FAPI PET/CT and 99mTc-CTR-FAPI SPECT

For 68Ga-FAPI PET/CT scan,each patient was injected with 1.8-2.2 MBq/kg (0.05-0.06 mCi/kg) body weight of 68Ga-FAPI. PET/CT from skull to feet was performed 60±5 min post-injection. For 99mTc-CTR-FAPI SPECT scan:each patient was injected with 10-20mCi 99mTc-CTR-FAPI . Planar SPECT scan and SPECT/CT were performed 60±5 min post-injection.


Locations(1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

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NCT07138729


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