RecruitingNot ApplicableNCT07139314

Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2

Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation: a Randomised Controlled Trial

Sponsor

Capital Medical University

Enrollment

240 participants

Start Date

Sep 24, 2025

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation Ischemic Stroke

Summary

This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation after endovascular treatment.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study (the companion to Trial 29) is also investigating the best timing for starting blood thinners after emergency clot-removal surgery for stroke in patients who have atrial fibrillation — but focuses on patients with a more significant type of bleeding in the brain after the procedure. **You may be eligible if...** - You are 18 or older - You had an acute ischemic stroke caused by a blocked large blood vessel - You received emergency endovascular clot-removal therapy within 24 hours of stroke onset - You have atrial fibrillation (confirmed by ECG or medical records) - Your brain scan shows a specific pattern of blood within the stroke area (parenchymatous hematoma type 1 or 2) **You may NOT be eligible if...** - Your brain bleeding is extensive or involves a large mass effect - You have reasons you cannot safely take blood thinners - You are under 18 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEarly anticoagulation

Early initiation of direct oral anticoagulants will be started within 4 weeks after symptom onset.

DRUGDelayed anticoagulation

Delayed initiation of direct oral anticoagulants will be started between 4-8 weeks after symptom onset.

Locations(37)

Ma'anshan People's Hospital

Ma’anshan, Anhui, China

Xuanwu Hospital

Beijing, Beijing Municipality, China

Aviation General Hospital

Beijing, Beijing Municipality, China

Beijing Shijingshan Hospital

Beijing, Beijing Municipality, China

Zhangzhou Municipal Hospital of Fujian Province

Zhangzhou, Fujian, China

Heyuan People's Hospital

Heyuan, Guangdong, China

Qinzhou First People's Hospital

Qinzhou, Guangxi, China

Baoding Sixth Hospital

Baoding, Hebei, China

The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China

The Hongda Hospital of Jiamusi University

Jiamusi, Heilongjiang, China

Fangcheng County People's Hospital

Nanyang, Henan, China

Nanyang Central Hospital

Nanyang, Henan, China

Lushan County People's Hospital

Pingdingshan, Henan, China

Xinyang Central Hospital

Xinyang, Henan, China

Queshan County People's Hospital

Zhumadian, Henan, China

Tianyou Hospital, Wuhan University of Science and Technology

Wuhan, Hubei, China

Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, China

Yingkou Central Hospital

Yingkou, Liaoning, China

Ordos Central Hospital,

Ordos, Neimenggu, China

Feicheng Hospital Of Shandong Yiyang Health Group

Feicheng, Shandong, China

Jinan Zhangqiu District People's Hospital

Jinan, Shandong, China

Qilu Hospital of Shandong University

Jinan, Shandong, China

Laizhou City People's Hospital,

Laizhou, Shandong, China

Linyi People's Hospital

Linyi, Shandong, China

Linshu County People's Hospital

Lishui, Shandong, China

Yantai Yeda Hospital

Yantai, Shandong, China

Guoyao Northern Hospital (Baotou)

Baotou, Shanxi, China

ShanXi Cardiovascular Hospital

Taiyuan, Shanxi, China

The Second Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, China

Guoluo Prefecture People's Hospital

Guoluo, China

Huanghua Municipal People's Hospital

Huanghua, China

First Affiliated Hospital of Henan Polytechnic University

Jiaozuo, China

Ningjin County People's Hospital

Ningjin, China

Ren Shou County People's Hospital

Renshou, China

Daliuta Experimental District People's Hospital of Shenmu City

Shenmu, China

Xiuyan Central Hospital

Xiuyan, China

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, China

View Full Details on ClinicalTrials.gov

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NCT07139314

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Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2

Conditions

Summary

Eligibility

Plain Language Summary

Interventions

Locations(37)

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