Obe-cel in Refractory Progressive Forms of Multiple Sclerosis

This study is testing a CAR-T cell therapy called obe-cel — where immune cells are engineered to attack abnormal immune cells — in people with progressive forms of multiple sclerosis (MS) that have not responded to other treatments. It is based on the idea that MS is driven by immune cells that can be targeted with this approach. **You may be eligible if...** - You are 18 to 60 years old - You have been diagnosed with a progressive form of MS (primary or secondary progressive) - You have tried at least 2 disease-modifying MS therapies without adequate benefit - You are not pregnant or breastfeeding **You may NOT be eligible if...** - You have highly active or rapidly progressing MS - You have another autoimmune central nervous system condition - You have an active or uncontrolled infection (bacterial, viral, or fungal) - You have a history of certain cancers (unless you have been cancer-free for several years) - You are taking prohibited medications Talk to your doctor to see if this trial is right for you.